From HIV to COVID-19, Molecular mechanisms of pathogens' trade-off and persistence in the community, potential targets for new drug development.

Background: On the staggering emergence of the Omicron variant, numerous questions arose about the evolution of virulence and transmissibility in microbes. Main body of the abstract: The trade-off hypothesis has long speculated the exchange of virulence for the sake of superior transmissibility in a wide array of pathogens. While this certainly applies to the case of the Omicron variant, along with influenza virus, various reports have been allocated for an array of pathogens such as human immunodeficiency virus (HIV), malaria, hepatitis B virus (HBV) and tuberculosis (TB). The latter abide to another form of trade-off, the invasion-persistence trade-off. In this study, we aim to explore the molecular mechanisms and mutations of different obligate intracellular pathogens that attenuated their more morbid characters, virulence in acute infections and invasion in chronic infections. Short conclusion: Recognizing the mutations that attenuate the most morbid characters of pathogens such as virulence or persistence can help in tailoring new therapies for such pathogens. Targeting macrophage tropism of HIV by carbohydrate-binding agents, or targeting the TMPRSS2 receptors to prevent pulmonary infiltrates of COVID-19 is an example of how important is to recognize such genetic mechanisms.

Cedar Wood-Based Biochar: Properties, Characterization, and Applications as Anodes in Microbial Fuel Cell.

In this study, the relationship between pyrolysis temperature of woody biomass and physicochemical properties of derived biochar was investigated for microbial fuel cell (MFC) application. Physical and chemical properties of biochar were characterized for different pyrolysis temperatures. Results showed that biochar obtained at 400 °C was not conductor, while biochars prepared at 600 °C, 700 °C, and 900 °C exhibited decreased electrical resistivity of (7 ± 6) × 103 Ω.m, (1.8 ± 0.2) Ω.m, and (16 ± 3) × 10-3 Ω.m, respectively. Rising pyrolysis temperature from 400 to 700 °C exhibited honeycomb-like macroporous structures of biochar with an increase in the specific surface area from 310 to 484 m2.g-1. However, the production of biochar at 900 °C reduced its specific surface area to 136 m2.g-1 and caused the loss of the ordered honeycomb structure. MFCs using anodes based on biochar prepared at 900 °C produced maximum power densities ((9.9 ± 0.6) mW.m-2) higher than that obtained with biochar pyrolyzed at 700 °C ((5.8 ± 0.1) mW.m-2) and with conventional carbon felt anodes ((1.9 ± 0.2) mW.m-2). SEM images of biochar-based anodes indicated the clogging of macropores in honeycomb structure of biochar prepared at 700 °C by growth of electroactive biofilms, which might impede the supply of substrate and the removal of metabolites from the inside of the electrode. These findings highlight that electrical conductivity of biochar is the major parameter for ensuring efficient anodes in microbial fuel cell application. Schematic representation of cedar wood-based biochar and its application as anode in MFC.

AlN hollow-nanofilaments by electrospinning.

We present for the first time an original method to elaborate AlN nanofilaments (NFs) by using a preceramic-based electrospinning process. Initially, an Al-containing precursor (poly(ethylimino)alane) is mixed with an organic spinnable polymer to be electrospun and generate polymeric filaments with a homogeneous diameter. A ceramization step at 1000 °C under ammonia and a crystallization step at 1400 °C under nitrogen are performed to get the final product made of AlN NFs with a diameter ranging from 150 to 200 nm. Studies carried out by high resolution electron microscopy and 3D tomography show their regular morphology, with high chemical purity and polycrystalline nature.